Health News and Scoops

Teva Neuroscience, Inc. today presented results from a clinical pharmacology study in which AZILECT (rasagiline tablets) did not increase the risk of tyramine sensitivity at the maximum approved dose of 1 mg. The presentation was made during the 13th International Congress of Parkinson’s Disease and Movement Disorders in Paris, France.

This study assessed the potential risk of hypertensive crisis due to the interaction between high doses of oral tyramine and therapeutic doses of rasagiline, which is indicated both as monotherapy in patients with early Parkinson’s disease (PD) and as adjunctive treatment in patients receiving levodopa. The study supported the selectivity of rasagiline for inhibition of MAO-B at currently approved doses.

“We are pleased with the results, which met our primary objectives,” said Jon Congleton, general manager of Teva Neuroscience. “This study provides continuing evidence of the value of AZILECT. The results demonstrated a low potential for MAO-A and therefore a selectivity for MAO-B inhibition.”

Tyramine is an amino acid found in certain foods and beverages, including some air-dried and fermented meats, some aged cheeses and most soybean products. Nonselective MAO inhibitors, such as phenelzine sulfate, interfere with the breakdown and elimination of tyramine in the body.

Selective MAO-B inhibitors do not interfere with tyramine breakdown and elimination. Patients who take nonselective MAO inhibitors need to be cautious with the foods they eat to prevent an abnormal build-up of tyramine, which could lead to an episode of extremely high blood pressure, potentially leading to stroke or heart attack.

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The different types of physical therapy are: cardiopulmonary, geriatric, integumentary, neurologic, orthopedic, and pediatric.

Physical therapy is a noble health care profession specializing in assessing, evaluating, and treating individuals with disorders involving their musculoskeletal systems. The main goal of physical therapy is to improve and regain each patients’ physical function and achieve their normal fitness level while relieving pain caused by a certain disorder. Just like any physical therapy Los Angeles, treatment modalities are carried out by trained and licensed physical therapists when it is prescribed by the patient’s physician. The use of physical agents such as heat, cold, electricity, exercise, and massage varies in every patient and according to what area or type of physical therapy is needed. The different types of physical therapy are:

Cardiopulmonary

This type of physical therapy focuses on patients who suffer from cardiopulmonary disorders like heart attacks, chronic obstructive pulmonary disease, adult respiratory distress syndrome, or respiratory failure. This therapy also helps those who are recovering from cardiac or pulmonary surgeries. Its goal is to increase each patient’s respiratory endurance by helping to clear lung secretions and restore normal heart and breathing rate without causing complications through manual therapies, like mobilization and massage.

Geriatric

As we get older, our bodies age. having an older body is often accompanied by conditions that affect our movement and gradually impedes our functionality. The primary focus of geriatric therapy is on aging adults, most preferably those who have arthritis, cancer, Alzheimer’s disease, Parkinson’s disease, osteoporosis, and so on.

Integumentary

Integumentary physical therapy helps in the treatment of skin issues like burns or wounds. Its goals are to promote tissue healing and proper blood circulation around the organ and to clean or remove necrotic tissues that can potentially cause more injury or even immobility. The use of dressings, topical agents, mechanical lavage, traction, exercises, splints, and edema control are very common in this area.

Neurologic

Patients who have neurological disorders that need physical treatment are under this type of physical therapy. These patients are those who have Alzheimer’s disease, Parkinson’s disease, cerebral palsy, or multiple sclerosis or who are recovering from a brain injury, stroke, spinal cord injury and must overcome physical dysfunctions such as paralysis, poor balance, or involuntary muscle movements.

Orthopedic

Orthopedic physical therapy deals with patients who have musculoskeletal disorders. Therapists treat patients recovering from orthopedic surgery or who are dealing with, post-operative joint pain, arthritis, sprains, fractures, and even amputations. Treatment can include the use of electrical stimulation, strength training, joint mobilizations, and hot or cold compressions. The course of the treatments is only done in the out-patient department.

Pediatric

Pediatric physical therapy helps in the treatment of various physical health problems or disorders in younger people–infants, children, or adolescents. These patients are those experiencing congenital, neuromuscular, skeletal, or development disorders. Examples of which are cerebral palsy or spina bifida patients who have trouble with their motor and cognitive skills. The main goal of this type of physical therapy is to improve the overall fitness status of the patient.

The best way to achieve the desired health outcome with patients having mobility disorder is to go to the doctor for regular check ups. If physical therapy is advised, choose the area that specializes in the disorder for faster and effective results.

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Freezing of Gait (FOG) is an often incapacitating symptom common in Parkinson’s disease. Parkinson’s patients experiencing FOG feel as if their feet are glued to the floor. Will power to keep moving has no effect, leaving the Parkinson’s patient frozen in place. The associated physical and psychosocial consequences have a great impact on the patients’ quality of life, and injuries are common as the end result is often falling.

Neurologists prescribe pharmaceuticals commonly causing an array of side effects including mood changes and hallucinations. Furthermore, at advanced stages, FOGs are resistant to treatment with medications.

The resultant loss of independence and treatment costs of injuries add substantially to the health care expenditures associated with Parkinson’s disease.

Doctors have known for over 50 years that Parkinson’s patients suffering from FOG can walk almost normally when certain visual cues are placed in their path. The use of tranverse lines drawn on the floor have been studied extensively with good results.

Some challenges have kept this treatment strategy from leaving the clinical study setting:

1. The requirement of drawing cues on the ground in the patient’s own environment.
2. The distance between the visual cues needs to be regularly adjusted to be appropriate for different ways of walking during different parts of the day and at different days.

The GaitAid device was developed to provide the benefits of this treatment strategy while solving these problems. It provides easy to use state of the art technology to display these cues through special glasses. The device provides cues which are automatically appropriate for each step taken no matter how big or fast. It is like having an expert physical therapist at your disposal drawing the cue needed for your next step just where it needs to be. In addition, clinical research has shown that, by providing separate cues for each foot as provided by the GaitAid, the improvement is two fold what was achieved by the transverse lines (same for both feet) strategy.

The GaitAid is the first device to offer a lasting improvement in walking as opposed to other devices on the market targeting FOG. With the GaitAid, one has the opportunity to train and improve so that later improved walking is possible without the device.

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